Club Nacional are travelling to Peru to face Alianza Lima in a cruical match. They played a 1-1 draw in Paraguay during the first leg. Nacional then rotated, and lost against Recoleta FC. Now they will once again go "all in" in Lima, on the 13th.
With the schedule being so hectic, Nacional are expected to return to Paraguay facing Guarani on the 15th, basically with two days of rest, and will have to manage their squad after quick turnaround, and heavy rotation is expected here yet again. The only team benefiting from that will be Guarani, with more rest and preparation.
Guarani are also a very solid team, but they will miss their goalkeeper Gaspar Servio due to suspension.
Francesco Arce (coach) is 16-16-6 with Guarani, so only 6 losses in 38 matches is impressive. They are a solid performing team.
Conclusion: The market has already responded to this scenario, with decreasing odds on Guarani as they will have a huge advantage squad wise. They also rarely lose outright, so I think a safe position to take here is DNB Guarani. Most likely will continue to drop