Empoli is one of the weakest squad in this league and I think they have the worst defense ever seen in past 2 years in Serie A league.
They still miss they main goalkeeper and I cant see them doing well in Rome.
Roma need to win as they did not achieve one in their first 3 games, they had some problem in defense and conceded too much space from defense to midfield and some players were forced to act a role that its not their own, forx example Smalling hasnt seen in offensive actions since hes forced to go back defense for 20-30meters.
Mourinho is a trainer that usually play well in defense so I expect a better situation since has passed 2 weeks from last recent Serie A games and they had time to focus and work on-for it.
Buona fortuna!