The hosts are desperately fighting to distance themselves from the relegation zone, while the visitors from Pamplona remain in the top half of the table and are dreaming of European competition. Both teams' recent results suggest a very close match.
Osasuna arrives in Valencia in solid form, having not lost any of their last five league matches.
Matches at the Estadio de Mestalla always carry a heavy emotional load, but the hosts' current situation puts enormous pressure on them to win.
Valencia currently sits 16th in the table and must pick up points to avoid being permanently embroiled in a relegation battle.
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